Scientist Profile

Dr. Kanthi Kiran Kondepudi

Dr. Kanthi Kiran Kondepudi

Scientist-E

Date of Joining: 02 Sep 2011

+91 172 522 1246

Broad Area: Food & Nutritional Biotechnology 

Specialization: Metabolic diseases, Gut Bacteria, Metagenomics, Functional Foods, Cereal Dietary fibers, Probiotics & Prebiotics

Post-doctoral Fellow at the Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Sweden from May 2009 to Aug 2011

Mentors: Prof. Torkel Wadström and Prof. Åsa Ljungh 

Research Porject: The Development of Next-Generation Probiotics and Prebiotics for the Prevention and Treatment of Clostridium difficile Associated Diarrhea (CDAD), funded by EU under FP7-SME, Project no: 232087 (https://www.cordis.europa.eu/result/rcn/58245_es.html)

 

  1. Our group, for the first time, suggested that whole grain and bran of finger millet and Kodo millet supplementation could protect from high-fat diet induced lipid derangements and inflammatory status.
  2. Millets supplementation could beneficially modulate gut bacteria and protects from high-fat diet induced metabolic alterations.
  3. This is the first experimental evidence on the protective role of these millets in diet-induced obesity (DIO).
  4. Our metagenomic based studies suggested that arabinoxylan, a non-starch dietary fiber, could alleviate the high-fat diet induced obesity in mice. The beneficial effects of AX from Finger Millet are mainly due to stimulation of healthy gut bacteria and release of propionic acid, which is a short chain fatty acid besides beneficial changes in adipose tissue, liver, and intestine. 

 

Targeting Inflammation

Recent studies suggested a link between obesity and gut microflora. Proinflammatory “Lipopolysaccharide (LPS)” originating from Gram-negative bacteria and other bacterial metabolites translocate to the circulation causing low-grade inflammation (endotoxemia) associated with obesity. Our research goal is to develop functional foods that could beneficially modulate gut microflora and protect from inflammation underlying obesity and metabolic syndrome.

Accordingly, our group is working on two research areas

1.  Role of cereals and millets and their bioactive ingredients (dietary fibers and other phytochemicals) in mitigating life style associated diorders.

2.  Evaluation of probiotics and prebiotic for thier protective role under gut inflammatory conditions.

We employ diet-induced obese rodent models, nutrigenomic and metagenomic approach in our studies.

  1. Singh S, Bhatia R, Khare P, Sharma S, Rajarammohan S, Bishnoi M, Bhadada SK, Shyam SS, Kaur JKondepudi KK (2020). Anti-inflammatory Bifidobacterium strains prevent Dextran Sodium Sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep. 10:18597.

  2. Khare P, Mourya R, Bhatia R, Mangal P, Singh J, Bishnoi M, Kondepudi KK (2020). Polyphenol Rich Extracts of Finger and Kodo Millet Ameliorates High Fat Diet-Induced Metabolic Alterations. Food Funct., https://doi.org/10.1039/D0FO01643H

  3. Khanna S, Walia S, Kondepudi KK, Shukla G. (2020) Administration of indigenous probiotics modulate high-fat diet-induced metabolic syndrome in Sprague Dawley rats. Antonie van Leeuwenhoek 113, 1345–1359 (2020).

  4. Chander AM, Singh S, Sharma S, Chaudhry V, Rajarammohan S, Mantri SS, Bishnoi M, Bhadada SK, Kondepudi KK (2020). Draft Genome Sequence of Bifidobacterium pseudocatenulatum Bif4, Isolated from Healthy Infant Feces. Microbiol Resour Announc. 9(26): e00561-20.

  5. Pabari K, Pithva S, Kothari C, Purama RK, Kondepudi KK, Vyas BRM, Kothari R, Ambalam P. (2020). Evaluation of probiotic properties and prebiotic utilization potential of Weissella paramesenteroides isolated from fruits. Probiotics Antimicrob Proteins. 2020 Jan 16. doi: 10.1007/s12602-019-09630-w.

  6. View All Publication
  7. Monga N, Sethi GS, Kondepudi KK, Naura AS. (2020) Lipid mediators and asthma: Scope of therapeutics. Biochem Pharmacol. Mar 23:113925. doi: 10.1016/j.bcp.2020.113925.

     

  8. Singh R, Bansal Y, Sodhi RK, Singh DP, Bishnoi M, Kondepudi KK, Medhi B, Kuhad A. (2020). Berberine attenuated olanzapine-induced metabolic alterations in mice: Targeting transient receptor potential vanilloid type 1 and 3 channels. Life Sci. Apr 15;247:117442. doi: 10.1016/j.lfs.2020.117442. Epub 2020 Feb 17. 

  9. Khanna S, Bishnoi M, Kondepudi KK, Shukla G. (2020). Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulted RAW 264.7 macrophages. World J Microbiol Biotechnol. May 9; 36(5):74.

  10. Sharma N, Kondepudi KK, Gupta N. (2019). Screening of Ethnic Indian Fermented Foods for Effective Phytase Producing Lactic Acid Bacteria for Application in Dephytinization of Phytate Rich Foods.  International Journal of Scientific Research 6 (2), 1-7. 

  11. Sarma SM, Singh DP, Singh P, Khare P, Mangal P, Singh S, Bijalwan V, Boparai RK, Kaur J, Mantri S, Boparai RK, Mazumder K, Bishnoi M†, Bhutani KK, Kondepudi KK† (2018). Finger millet arabinoxylan protects mice from high-fat diet induced lipid derangements, inflammation, endotoxemia and gut bacterial dysbiosis. Int J Biol Macromol., 106:994-1003. 

  12. Singh S, Bhatia R, Singh A, Singh P, Kaur R, Khare P, Purama RK, Boparai RK, Rishi P, Ambalam P, Bhadada SK, Bishnoi M, Kaur J, Kondepudi KK. Probiotic attributes and prevention of LPS-induced pro-inflammatory stress in RAW264.7 macrophages and human intestinal epithelial cell line (Caco-2) by newly isolated Weissella cibaria strains. Food Funct. 2018, 9(2):1254-1264. 

  13. Dhaliwal J, Singh DP, Singh S, Pinnaka AK, Boparai RK, Bishnoi M, Kondepudi KK, Chopra K.. Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice.J Appl Microbiol. 2018, 125(1):257-269. 

  14. Deol PK, Khare P, Bishnoi M, Kondepudi KK, Kaur IP. Coadministration of ginger extract-Lactobacillus acidophilus (cobiotic) reduces gut inflammation and oxidative stress via downregulation of COX-2, i-NOS, and c-Myc. Phytother Res. 2018, doi: 10.1002/ptr.6121. 

  15. Deol PK, Khare P, Singh DP, Soman G, Bishnoi M, Kondepudi KK, Kaur IP. Managing colonic inflammation associated gut derangements by systematically optimised and targeted ginger extract-Lactobacillus acidophilus loaded pharmacobiotic alginate beads. Int J Biol Macromol. 2017 Dec;105(Pt 1):81-91.

  1. Certificate of appreciation for securing 2nd rank in the PhD comprehensive exam at Department of Chemistry, IIT Madras, Chennai, India.
  2. Qualified Graduate Aptitude Test of Engineering (GATE 2002); Life Sciences; 88.4 percentile.
  3. Cash prize for Distinction at Master of Science in Biochemistry (3rd rank in the University) during 1999-2001
  4. Certificate for getting highest marks in Biochemistry during B.Sc. 1st Year, in 1996