Dr. Pramod Kaitheri Kandoth
Plant Molecular Biology and Biochemistry, Functional genomics, Genomics
- 1998-2004 Ph. D. Department of Biochemistry, Indian Institute of Science, Bangalore.
- 2005-2007 Postdoctoral Fellow, Department of Biological Sciences, University of South Carolina, Columbia, SC, USA
- 2007- 2012 Postdoctoral Fellow, Division of Plant Sciences, University of Missouri, Columbia, MO, USA
- 2012-2017 Research Associate, Division of Plant Sciences, University of Missouri, Columbia, MO, USA
Lathyrus (Lathyrus sativus) is a nutrient rich, drought tolerant legume of immense economic importance but has not been widely cultivated, because of the presence of neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP) in the seeds that causes neurological disease, lathyrism. Genes and genetic factors determining ODAP production need to be understood to facilitate optimization of the strategies to develop low or no ODAP cultivars. Many genes in the biochemical pathway leading to the production of β-ODAP have not been cloned yet. Our strategy is to combine genetic, genomic and biochemical approaches to identify genes and their function leading to biotechnological applications including genome editing. These studies combined with plant breeding will help in developing low or no β-ODAP in the background of elite cultivars. Other interests include folate bio fortification in crop plants.
Verma A, Nidhi N, Kaur G, Mantri S, SharmaTR, Pandey AK, Kandoth PK, 2022. Contrasting β-ODAP content correlates with stress gene expression in Lathyrus cultivars. Physiol. Plant 174-1 https://doi.org/10.1111/ppl.13616 (Corresponding author)
Kaur N, Kandoth P. K., 2021.Tomato bZIP60 mRNA undergoes splicing in endoplasmic reticulum stress and in response to environmental stresses. Plant Physiol Biochem.160: 397-403 https://doi.org/10.1016/j.plaphy.2021.01.033 (Corresponding author)
Korasick DA, Kandoth PK, Tanner JJ, Mitchum MG, and Beamer LJ (2020) Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode J. Biol. Chem. 95: 3708-3718. doi:10.1074/jbc.RA119.012256
Kandoth, P.K., Liu, S., Prenger, E., Ludwig, A., Lakhssassi, N., Heinz, R., Zhou, Z., Howland,A., Joshua Gunther,J., Eidson, S., Dhroso, A., LaFayette, P., Tucker, D., Johnson, S., Anderson, J ., Alaswad, A., Cianzio, S R., Wayne A. Parrott,W. A., Korkin, D., Meksem, K., Mitchum, M. G. (2017). Systematic Mutagenesis of Serine Hydroxymethyltransferase Reveals an Essential Role in Nematode Resistance. Plant Physiol. 175: 1370-1380.
Liu,S., Kandoth, P. K., Lakhssassi, N., Kang, J., Colantonio, V., Heinz, R., Yeckel, G., Zhou, Z., Bekal, S., Dapprich, J., Rotter, B., Cianzio, S., Mitchum, M.G., Meksem, K. (2017). The soybean GmSNAP18 gene underlies two types of resistance to soybean cyst nematode. Nature Communications 8, 14822.View All Publication
Liu,S., Kandoth, P.K., Warren, S.D., Yeckel, G., Heinz, R., Alden, J., Yang, C., Jamai, A., ElMellouki, T., Juvale, P.S., Hill, J., Baum, T.J., Cianzio, S., Whitham, S. A., Korkin, D., Mitchum, M.G., Meksem K. (2012). A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens. Nature 492: 256–260. (equal contribution).
Kandoth, P.K., Ithal, N., Recknor, J., Maier, T., Nettleton, D., Baum, T.J., Mitchum, M.G. (2011). The soybean Rhg1 locus for resistance to the soybean cyst nematode Heterodera glycines regulates expression of a large number of stress- and defense-related genes in degenerating feeding cells. Plant Physiol. 155: 1960-75. (equal contribution).
Kandoth, P.K., Ranf, S., Pancholi, S.S., Jayanty, S., Walla, M.D., Miller, W., Howe, G.A., Lincoln, D.E., and Stratmann, J.W. (2007). Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin-mediated defense response against herbivorous insects. Proc Natl Acad Sci USA 104:12205–12210.