Scientist Profile

Food Science, Plant Metabolomics, Cancer Biology, and Nanotechnology

• MSc. Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra 431606, India.
• PhD. Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra 431606, India.
• Post-Doctoral Fellowship (March 2012- Feb 2014): Department of Bio-resources and Food Science, Konkuk University, Seoul. South Korea.
   

• Developed highly effective sub-critical water method for plant and food bioactive compound extraction and analysis.
• Formulated a polyherbal drug therapy for kidney stone treatment - commercial antiurolithiatic product.
• Extraction and utilisation of saffron and butea plant flowers biowaste extracted natural colorants for functional food development.
• Development of plant and food bioactive compound based phytomedicines & nanomedicines as future drug therapy for cancer, diabetics and kidney stone.
• Establishment of hairy root culture method for enhanced production of secondary metabolites.

Dr. Shivraj Nile’s lab at NABI mainly focused on analysis of food, herbal and natural bioactive compounds with their biological screening, chemical toxicology and therapeutic effects. The extracted bioactive compounds further utilized for development of functional foods, herbal drugs, nanomaterials, and biomaterials using various biochemical methods. Utilization and analysis of plant, fruit and food waste for extraction and production of value-added product including various nutrients, bio-sugars, phenolics and other bioactive phytochemicals. Extraction and stability analysis of natural colorants from plants and biowaste samples as an alternative for synthetic colorants. Valorisation of various wild and exotic edible fruits, flowers and vegetables in relation to their analysis for value added products as a food, cosmetic and natural drug ingredients. Studies are broadly aimed at understanding evaluation and molecular analysis of metabolites from medicinal plants, biowastes and their isolated compounds against different diseases including cancer, gout, diabetics, and kidney stone. Also, determination of enzyme inhibition, antioxidant, cytotoxic, and anti-inflammatory activities. Working on series of laboratory and large-scale experiments that were investigated for the utilization of fruit and vegetable biowastes, green extraction, bioactive compound analysis, and their effective delivery system with therapeutic effects, i.e., waste to health. Utilization of various novel green extraction methods like SWE, SCE, PHWE, and UAE for extraction of bioactive compounds from medicinal plants and various food products. Also, increasing solubility and bioavailability with decrease in toxicity using novel nanotechnologies and delivery systems for bioactive compounds and with their enhanced therapeutic effects.

Publications (Best Five)

1. Amruta Shelar, Shivraj Nile, et al., 2023. Recent Advances in Nano-Enabled Seed Treatment Strategies for Sustainable Agriculture: Challenges, Risk Assessment and Future Perspectives. Nano-Micro Letters, (2023), 15:54, 1-37.  https://doi.org/10.1007/s40820-023-01025-5
2. Min Shi, Pan Liao, Shivraj Nile, et a., 2021. Biotechnological exploration of transformed root culture for value-added products, Trends in Biotechnology, 39(2), 137-149. https://doi.org/10.1016/j.tibtech.2020.06.012 
3. Enkhtaivan Gansukh, Shivraj Nile, et al., 2020. New insights into antiviral and cytotoxic potential of quercetin and its derivatives – A biochemical perspective. Food Chemistry, 334 (2021), 127508.https://doi.org/10.1016/j.foodchem.2020.127508 
4. Arti Nile, Shivraj Nile, et al., 2021. Novel insights on the multi-functional properties of flavonol glucosides from red onion (Allium cepa L) waste- In vitro and in silico approach. Food Chemistry, 335, 2021, 127650. https://doi.org/10.1016/j.foodchem.2020.127650
5. Rohini Pungle, Shivraj Nile, et al., 2022. Green synthesis of silver nanoparticles using Tridax procumbens plant extract and screening of its antimicrobial and anticancer activities. Oxidative Medicine and Cellular Longevity. Volume 2022, Article ID 9671594, 14 pages, https://doi.org/10.1155/2022/9671594 

1. Highly Cited Researcher-2022, Clarivate™, London, United Kingdom, 15 November, 2022. 
2. Fellow of Maharashtra Academy of Sciences-2022 
3. “KU Research Pioneer Award”, Konkuk University, Seoul, Republic of Korea, 11 December, 2017. 
4. Young Scientist Award, ISNFF-2017, Gunsan, Republic of Korea, 22 October-2017. 
5. Science Slam Award, ISNFF-2017, Gunsan, Republic of Korea, 25 October-2017. 
6. Research Presentation Award, The National Science Academy of Science (NASI), India, 81st Annual Session of the Academy, Kerala, 26 November 2011 
7. Young Scientist Award, ICMPHP3-2011, Colombo, Sri Lanka, 21 December 2011. 
8. Young Scientist Award, ACB-2011, Shanghai, China, 15 May 2011. 
9. Young Scientist Award, CIPAM-2011, Cagliari, Italy, 15 April 2011. 
10. KU-Brain Pool Post-doctoral Research Fellowship (2012-2014) 
11. Junior Research Fellow -UGC, New Delhi-India (2005-2007).  
12. Senior Research Fellow -UGC, New Delhi-India (2008-2010).